兔抗人、大、小鼠多药耐药蛋白/P-糖蛋白抗体

中文名称：

 兔抗人、大、小鼠多药耐药蛋白/P-糖蛋白抗体

英文名称：

 Anti-MDR1/p-GP/CD243

产品编号：

 PL031468R

产品规格：

 0.1mg/0.2mg

包装情况：

一支包装（原装进口、分装）

其他名称：

 P-Glycoprotein; Multi Drug Resistance Associated Protein, ABCB1; ATP-binding cassette sub-family B (MDR/TAP), member 1; ABC20; CD243; CD243 antigen; CLCS; Multidrug resistance protein 1; P glycoprotein 1; p-GP; gp170; P gp; PGY1.

背景介绍：

 P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

交叉反应
       物 种：

· Rabbit Polyclonal IgG, affinity purified by Protein A. 
       · Reacts with: hu, mo, rat